Episode 85: Could It Be Epstein-Barr? The Hidden Virus Behind Fatigue, Autoimmunity & Thyroid Issues
Are you constantly tired, inflamed, or foggy, yet your labs say everything’s “normal”? You might be dealing with Epstein-Barr virus (EBV) reactivation, a hidden but powerful trigger behind chronic fatigue, autoimmune flare-ups, and thyroid issues like Hashimoto’s thyroiditis. In this episode, we dive deep into the EBV puzzle and explain how this latent virus, often picked up as mono or glandular fever, can silently affect your health for years after the initial infection.
You'll learn how EBV reactivation mimics conditions like hypothyroidism, chronic illness, and even perimenopausal burnout. We cover common symptoms like brain fog, low immunity, and ongoing exhaustion, and explore why standard lab tests often miss Epstein-Barr’s impact. You'll also hear about the growing research linking EBV to immune dysfunction, inflammation, and long-term autoimmunity.
We also share a functional medicine approach to uncovering and addressing EBV, focusing on testing, immune modulation, nutrition, and lifestyle changes. If you’ve been told “everything is fine” but still feel far from it, this episode will help you connect the dots. Whether you're battling persistent symptoms or looking for a natural way to heal from EBV, this conversation offers both clarity and the next steps.
DISCLAIMER: The content in this podcast and related website is not intended to be a substitute for medical advice. It is not intended to be used to diagnose or treat, instead it is designed to help educate and inspire. Always seek the advice of a professional medical practitioner or qualified health practitioner. Never ignore or disregard advice given to you based on information in this podcast or related website and do not delay in seeking medical advice.
Timestamps:
[02:45] - What is Epstein-Barr virus (EBV)?
[04:28] - Latent vs. Reactivated EBV: What’s the difference?
[07:08] - How EBV impacts immune regulation and triggers autoimmunity
[09:28] - Why the thyroid is especially vulnerable to EBV
[10:05] - EBV and its strong link to multiple sclerosis (MS)
[12:45] - How functional medicine tests for EBV reactivation
[15:08] - When testing for EBV is worth considering
[16:15] - Top triggers of EBV reactivation seen in clinical practice
[20:15] - What to do if you suspect EBV is at the root of your symptoms
“Most standard medical approaches only flag a current infection. So if your IgM is negative, you’ll be told that there’s nothing to worry about. But we know 90-95% of people have had EBV. What we want to know is, is your immune system showing signs of ongoing activation or reactivation? This is much more important information.”
Essential learnings from this episode…
EBV is more than just mono. Over 90% of adults carry Epstein-Barr virus, but it can silently reactivate during times of stress, burnout, or immune imbalance, triggering chronic symptoms.
Reactivated EBV can mimic other conditions. Symptoms like brain fog, joint pain, and extreme fatigue often look like thyroid disorders, burnout, or autoimmune flares.
The thyroid is a prime target. EBV has been found to reside in thyroid tissue and may contribute to ongoing inflammation in conditions like Hashimoto’s thyroiditis.
Standard labs often miss EBV reactivation. Functional medicine looks beyond basic IgM testing to detect subtle immune patterns and early antigen levels that reveal viral activity.
Chronic stress is a major trigger. Emotional trauma, poor sleep, overwork, or even nutrient depletion can create the perfect storm for EBV to reactivate.
Recovery focuses on immune modulation, nervous system support, nutrient replenishment, and reducing total body burden to restore energy and resilience.
EPISODE 85
Important links & mentions from this episode
Episode 1 with Athlete Lina Nielsen
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